In this article, we’ll be looking at the smart drug sunifiram, along with how it compares to other nootropics on the market. If you’re looking for more natural options, we suggest checking out our best nootropics page here.
What is Sunifiram?
Sunifiram (1-benzoyl-4-propanoylpiperazine) is a nootropic which is technically an experimental drug which has been seen to deliver strong memory boosting and antiamnesic effects in animal studies.
It was first invented in 2000 by Italian scientists from the University of Firenze. Sunifiram is from the racetam family and is in fact a derivative of Piracetam iteself.
Online it’s sometimes referred to as super piracetam, claimed to be over 1000 times more potent than piracetam itself.
In research it is being used to fight the effects of amnesia and is even being studied for treating Alzheimer’s disease and other conditions which cause cognitive decline. It’s even been used in a passive avoidance test.
Other benefits reported from Sunifiram include improvements to both mood and energy, which can occur even in smaller doses.
One of the major problems that Sunifiram faces at the moment is peer review research. Without many studies observing Sunifiram – especially in humans – extent of benefits, and more importantly dangers are largely unknown.
To us, sunifiram is not fit for human consumption. However, in this article we will explore reported effects along with other interesting topics regarding the Sunifiram drug.
- Formula: C14H18N2O2
- Molar mass: 246.304 g/mol
- ChemSpider ID: 3432996
- ChEMBL Id: 309176
- Improved Learning and Memory
- Treatment for Amnesia
- Better Focus and Clarity
- Increases in Mood and Energy – also known as a sunifiram high
- Boosts in Sex Drive
The benefits of the drug Sunifiram are believed to come from how it affects the AMPA receptors in your brain.
An AMPA receptor can increase glutamate production and high neural activatoin for better overall memeory.
AMPA receptors can also help with releasing acetylcholine, which is your brain’s learning neurotransmitter.
This is all possible by sunifiram being an ampakine which allows it to affect the AMPA receptor and give this output. It also makes it a stimulant which improves your overall energy and alertness – but it apparently does so without the jitters. Anecdotally, biohackers recommend a Sunifiram dosage of 5 – 10 mg, 3 times a day.
Sunifiram Side Effects: Is it safe?
As we’ve mentioned, many vendors claim that sunifiram is not fit for human consumption. In addition to this, numerous side effects have been reported with abuse of the drug.
Here are some of the more reported problems:
- Mental Sluggishness (“Brain Fog”)
The intensity of these side effects are linked to the higher the dosage. The more you take, the bigger risk you have of developing these problems.
Erowid is a website that collates experiences of nootropics, psychoactive plants and other chemicals.
But what are they saying about Sunifiram?
On the actual site, no specific anecdotes or summaries of sunifiram have been recorded. However, the forum does have some chatter about the drug from as early as 2003.
Although it does not go into detail of any use of the smart drug. The user discussing sunifiram was impressed with the idea that it may help fight the amnesia effect induced by scopolamine. Scopolamine being a drug which has been used to spike unsuspecting victims into a zombie-like state by devious criminals.
This no credible researched evidence or studies which show that drug sunifiram is a suitable choice for bodybuilding or weight loss.
However, some of the benefits tied to this drug may lend itself to the bodybuilding process.
Sunifiram has some stimulating effects and boosts to concentration which may help with motivation and performance in the gym.
Although none of this is recommended without suitable guidance from a medical expert or doctor.
Buy Sunifiram Capsules
Disclaimer: If you’re looking to do a sunifiram buy you should only be doing in the spirit of research purposes – and not with the intention to do any form of human consumption.
That said there are numerous vendors out there that are able to ship Sunifiram throughout the United States. Do with that information what you will.
Sunifiram Nootropics Depot
Is Sunifiram available from the Nootropcis Depot?
No it isn’t (at the time of writing this). We have searched the Nootropics Depot site for any information regarding the sale of sunifiram and it doesn’t seem to be available for purchase on their website.
Sunifiram for ADHD
Still being in an experimental phase – we cannot recommend Sunifiram for ADHD on this information, however we can compile anecdotal experiences of others who are using this nootropic to treat the condition.
From the majority of reports that we’ve read reegarding Sunifiram and ADHD, the main effects seem to kick in after a few days. With days 1 – 3 being next to unnoticeable. After that, the subjects reported an improvement in memory and focus and help negate the negative effects associated with ADHD.
This is all well and good, but we suggest that you speak to your doctor or a medical professional before pursuing sunifiram to make sure that it is the right choice for you.
Unifiram vs Sunifiram
Unifiram and sunifiram both have the main pharmacological properties of pirace- tam-like compounds: facilitation of memory processes, lack of toxicity and side effects, and lack of affinity towards the most important central receptors. However, unifiram and sunifiram differ from nootropics in their potency.
What is Unifiram?
Unifiram, like sunifiram is an experimental anti-amnesiac drug which has also been linked to vastly improving your overall memory.
Like Sunifiram, it is also thought to work numerous times better than piracetam according to numerous information sources.
It stimulates the production of the acetylcholine neurotransmitters in your brain to improve your overall memory and learning.
It also helps AMPA receptors as the mechanism of action which help with amnesia.
When it comes to the actual differences between Sunifiram and Unifiram, little differences have been noticed. However, more report an additional benefit of focus and cognitive function with unifiram, whereas Sunifiram users feel it helps more with learning and mental energy.
Unifiram Side Effects
Unifiram is even more experimental than sunifiram, the side effects are even less documented.
Users have noted experiencing:
- Brain Fog
To name just a few. The point is that you shouldn’t be looking to experiment with a drug not a lot of people have taken – or very few pieces of evidence exist for the actual effects of this nootropic.
Sunifiram vs Adrafinil
These are totally different nootropics, there was some overlap with sunifiram and unifiram in terms of memory – but adrafinil takes an entirely different approach. Here’s our information.
What is Adrafinil?
Adrafinil is a eugeroic which is used to promote alertness, attention, wakefulness, positive mood, and other parameters, particularly in the elderly. It is the precursor to modafinil which is a non-amphetamine based smart drug which can dramatically promote alertness and reduce the need for sleep.
Adrafinil can be used to fight narcolepsy and other fatigue related conditions – but as always it must be prescribed by a doctor before using.
It is primarily concerned with boosting overall wakefulness, cognitive boosts, energy levels and high-level cognition to keep you up and working for longer periods of time. Whereas Sunifiram is mainly concerned with boosting your memory and fighting amnesia.
Adrafinil Side Effects
There are significantly more users of Adrafinil than other drugs that we have covered in this article, therefore we can give a more detailed list of the side effects reported with adrafinil:
- Digestive Issues
- High Blood Pressure
- Increased Heart Rate
Many of which are associated with the stimulating effects of the drug.
Regardless, this is a nootropic that you should only use in line with medical advice from a doctor. It’s also important to note that both Adrafinil and Modafinil are banned substances by the World Anti Doping Association (WADA).
IDRA-21 vs Sunifiram
IDRA-21 is a nootropic which is claimed to be 30 times stronger than aniracetam.
It’s another Ampakine optoin that works with AMPA receptors in your brain to promote:
- Short Term Memory
- Working Accuracy
- Mental Focus
Again, the main difference between IDRA-21 and something like Sunifiram is that IDRA-21 helps more overall focus and cognitive effects. Whereas Suni can help more with memory.
If you’re looking memory boosters to research you should use and choose sunifiram over IDRA-21 according to our research.
What is IDRA-21?
IDRA-21 is a positive allosteric modulator of the AMPA receptor and a benzothiadiazine derivative. It is a chiral molecule, with-IDRA-21 being the active form. IDRA-21 shows nootropic effects in animal studies, significantly improving learning and memory. It is a good cognitive aid. But how safe is it?
IDRA-21 Side Effects
Again, like with all synthetic nootropics there are serious risks when taking them. You should always research and get advice / information from your doctor before taking them.
Here’s a list of the side effects associated with IDRA-21:
- Mood swings
- May also increase neuronal damage after stroke / seizure
Which can all become very serious and useful information. Again we do not recommend synthetic nootropics and suggest that the recommended dosages should always be followed – not abused – and be under medical supervision. Always do your research.
Sunifiram vs Adderall
There are incredible differences between Adderall and Sunifiram. You should have totally different aims for either nootropic. As we’ve mentioned, Suni helps with memory – Adderall is a product manufactured from amphetamine salts and can energize you to almost dangerous levels if used improperly.
What is Adderall?
Adderall (Mydayis) are trade names for a combination drug containing four different salts of amphetamine. It is composed of equal parts racemic amphetamine and dextroamphetamine, which makes a ratio between dextroamphetamine and levoamphetamine, which are the two enantiomers of amphetamine.
Adderall is totally different to Sunifiram as it is amphetamine-based and made to dramatically promote energy levels, whereas the latter is all about memory boosting.
Adderall Side Effects
There are plenty of side effects associated with Adderall aside from the cognitive benefits – both in animal studies and in human studies from research.
Here’s a list of some of the more common problems:
- Stomach ache
- Decreased appetite
- Trouble sleeping
- Dry mouth
There’s also more in terms of insomnia, quickened heart rate, higher blood pressure – most side effects you get from strong stimulants you may face with adderall.
You should always get some kind of medical advice from a doctor or health professional before using this kind of medication. Adderall is prescription only and should be treated with care.
If you’re looking for some natural alternatives to adderall – our best nootropics page may have what you need. We’ve compiled a list of the best options to get similar feelings to this prescription medication without taking the risk on your health.
If you’re interested about learning more – you can head over to our alternative adderall section here.